Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax3  paired box 3   (Synonyms: Pax-3, Splchl2)
Results	Reference
1	J:187740 Anderson C, Williams VC, Moyon B, Daubas P, Tajbakhsh S, Buckingham ME, Shiroishi T, Hughes SM, Borycki AG, Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev. 2012 Sep 15;26(18):2103-17
1	J:222437 Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA, Mef2c-F10N enhancer driven beta-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol. 2015 Jun 1;402(1):3-16
1	J:327968 Arostegui M, Wilder Scott R, Bose K, Michael Underhill T, Cellular taxonomy of Hic1(+) mesenchymal progenitor derivatives in the limb: from embryo to adult. Nat Commun. 2022 Aug 25;13(1):4989
1	J:336501 Asfour H, Hirsinger E, Rouco R, Zarrouki F, Hayashi S, Swist S, Braun T, Patel K, Relaix F, Andrey G, Stricker S, Duprez D, Stantzou A, Amthor H, Inhibitory SMAD6 interferes with BMP-dependent generation of muscle progenitor cells and perturbs proximodistal pattern of murine limb muscles. Development. 2023 Jun 1;150(11):dev201504
1*	J:304565 Bi-Lin KW, Seshachalam PV, Tuoc T, Stoykova A, Ghosh S, Singh MK, Critical role of the BAF chromatin remodeling complex during murine neural crest development. PLoS Genet. 2021 Mar;17(3):e1009446
1*	J:275243 Bosch PJ, Fuller LC, Weiner JA, A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo. Genesis. 2019 May;57(5):e23286
1	J:165285 Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chedotal A, Fortin G, Hindbrain interneurons and axon guidance signaling critical for breathing. Nat Neurosci. 2010 Sep;13(9):1066-74
1	J:97318 Brown CB, Engleka KA, Wenning J, Min Lu M, Epstein JA, Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice. Genesis. 2005 Apr;41(4):202-9
1	J:116769 Buckingham M, Bajard L, Daubas P, Esner M, Lagha M, Relaix F, Rocancourt D, Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential. Anat Embryol (Berl). 2006 Dec;211 Suppl 7:51-6
1	J:197199 Buckley DM, Burroughs-Garcia J, Lewandoski M, Waters ST, Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development. PLoS One. 2013;8(2):e56214
1	J:164695 Bush JR, Wevrick R, Loss of Necdin impairs myosin activation and delays cell polarization. Genesis. 2010 Sep;48(9):540-53
1	J:218594 Butler SJ, Bronner ME, From classical to current: Analyzing peripheral nervous system and spinal cord lineage and fate. Dev Biol. 2015 Feb 15;398(2):135-146
1	J:222441 Chang R, Petersen JR, Niswander LA, Liu A, A hypomorphic allele reveals an important role of inturned in mouse skeletal development. Dev Dyn. 2015 Jun;244(6):736-47
1	J:105245 Chen AE, Ginty DD, Fan CM, Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature. 2005 Jan 20;433(7023):317-22
1	J:337001 Cheng C, Cong Q, Liu Y, Hu Y, Liang G, Dioneda KMM, Yang Y, Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression. Sci Adv. 2023 Jun 16;9(24):eadf6927
1	J:105025 Cheung M, Chaboissier MC, Mynett A, Hirst E, Schedl A, Briscoe J, The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell. 2005 Feb;8(2):179-92
1*	J:163733 Christova T, Mojtahedi G, Hamel PA, Lymphoid enhancer factor-1 mediates loading of Pax3 to a promoter harbouring lymphoid enhancer factor-1 binding sites resulting in enhancement of transcription. Int J Biochem Cell Biol. 2010 May;42(5):630-40
1	J:279139 Cibi DM, Mia MM, Guna Shekeran S, Yun LS, Sandireddy R, Gupta P, Hota M, Sun L, Ghosh S, Singh MK, Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. Elife. 2019 Jun 26;8:e45418
1	J:143544 Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A, Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev Biol. 2009 Jan 1;325(1):225-37
1*	J:151956 Crist CG, Montarras D, Pallafacchina G, Rocancourt D, Cumano A, Conway SJ, Buckingham M, Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13383-7
1	J:278241 Delile J, Rayon T, Melchionda M, Edwards A, Briscoe J, Sagner A, Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord. Development. 2019 Mar 27;146(12):dev173807
1	J:127545 Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA, Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol. 2007 Nov 15;311(2):524-37
1	J:61431 Epstein JA, Li J, Lang D, Chen F, Brown CB, Jin F, Lu MM, Thomas M, Liu E, Wessels A, Lo CW, Migration of cardiac neural crest cells in Splotch embryos. Development. 2000 May;127(9):1869-78
1	J:335088 Escuin S, Rose Raza-Knight S, Savery D, Gaston-Massuet C, Galea GL, Greene NDE, Copp AJ, Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse. Dis Model Mech. 2023 Mar 1;16(3)
1	J:296619 Fan Y, Richelme S, Avazeri E, Audebert S, Helmbacher F, Dono R, Maina F, Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis. PLoS Genet. 2015;11(9):e1005533
1	J:333711 Ferdous A, Singh S, Luo Y, Abedin MJ, Jiang N, Perry CE, Evers BM, Gillette TG, Kyba M, Trojanowska M, Hill JA, Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circ Res. 2021 Oct 29;129(10):949-964
1*	J:122815 Giordani J, Bajard L, Demignon J, Daubas P, Buckingham M, Maire P, Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11310-11315
1	J:98519 Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
1	J:76658 Gross MK, Dottori M, Goulding M, Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16;34(4):535-49
1	J:56498 Gross MK, Moran-Rivard L, Velasquez T, Nakatsu MN, Jagla K, Goulding M, Lbx1 is required for muscle precursor migration along a lateral pathway into the limb. Development. 2000 Jan;127(2):413-24
1	J:177323 Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K, G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. J Exp Med. 2011 Apr 11;208(4):715-27
1	J:176192 Hayashi S, Rocancourt D, Buckingham M, Relaix F, Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
1	J:175786 Ho AT, Hayashi S, Brohl D, Aurade F, Rattenbach R, Relaix F, Neural Crest Cell Lineage Restricts Skeletal Muscle Progenitor Cell Differentiation through Neuregulin1-ErbB3 Signaling. Dev Cell. 2011 Aug 16;21(2):273-87
1	J:199287 Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, McMahon AP, Allen BL, Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013 Aug;140(16):3423-34
1	J:267950 Holzman MA, Bergmann JM, Feldman M, Landry-Truchon K, Jeannotte L, Mansfield JH, HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system. Int J Dev Biol. 2018;62(11-12):785-796
1*	J:187741 Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ, Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev. 2012 Sep 15;26(18):2088-102
1	J:252110 Iulianella A, Sakai D, Kurosaka H, Trainor PA, Ventral neural patterning in the absence of a Shh activity gradient from the floorplate. Dev Dyn. 2018 Jan;247(1):170-184
1*	J:327081 Jamet S, Ha S, Ho TH, Houghtaling S, Timms A, Yu K, Paquette A, Maga AM, Greene NDE, Beier DR, The arginine methyltransferase Carm1 is necessary for heart development. G3 (Bethesda). 2022 Jul 29;12(8)
1	J:236779 Junge HJ, Yung AR, Goodrich LV, Chen Z, Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord. Neural Dev. 2016 Oct 26;11(1):19
1*	J:98918 Kassar-Duchossoy L, Giacone E, Gayraud-Morel B, Jory A, Gomes D, Tajbakhsh S, Pax3/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev. 2005 Jun 15;19(12):1426-31
1	J:213766 Kicheva A, Bollenbach T, Ribeiro A, Valle HP, Lovell-Badge R, Episkopou V, Briscoe J, Coordination of progenitor specification and growth in mouse and chick spinal cord. Science. 2014 Sep 26;345(6204):1254927
1	J:114468 Konishi Y, Ikeda K, Iwakura Y, Kawakami K, Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 2006 Oct 20;1116(1):93-102
1	J:98802 Kriks S, Lanuza GM, Mizuguchi R, Nakafuku M, Goulding M, Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development. 2005 Jul;132(13):2991-3002
1	J:122955 L'honore A, Coulon V, Marcil A, Lebel M, Lafrance-Vanasse J, Gage P, Camper S, Drouin J, Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development. Dev Biol. 2007 Jul 15;307(2):421-33
1	J:137423 Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME, Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 2008 Jul 1;22(13):1828-37
1	J:200546 Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, Kormish J, Zaret KS, Buckingham ME, Relaix F, Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. PLoS One. 2013;8(5):e63143
1	J:167213 Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, Relaix F, Buckingham M, Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo. BMC Genomics. 2010;11:696
1	J:95257 Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY, The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development. Mol Cell Biol. 2004 Dec;24(24):10835-43
1	J:234106 Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z, NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife. 2016;5:e14264
1	J:326569 Leonard CE, Quiros J, Lefcort F, Taneyhill LA, Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia. Elife. 2022 Jun 17;11:e71455
1	J:174785 Luu B, Ellisor D, Zervas M, The lineage contribution and role of Gbx2 in spinal cord development. PLoS One. 2011;6(6):e20940
1	J:229604 Machon O, Masek J, Machonova O, Krauss S, Kozmik Z, Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40
1*	J:278508 Magli A, Baik J, Pota P, Cordero CO, Kwak IY, Garry DJ, Love PE, Dynlacht BD, Perlingeiro RCR, Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification. Nat Commun. 2019 May 24;10(1):2316
1	J:315934 Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA, Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Rep. 2014 Dec 11;9(5):1885-1895
1	J:99329 Martynoga B, Morrison H, Price DJ, Mason JO, Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol. 2005 Jul 1;283(1):113-27
1	J:212088 Mayeuf-Louchart A, Lagha M, Danckaert A, Rocancourt D, Relaix F, Vincent SD, Buckingham M, Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8844-9
1	J:240081 Mayeuf-Louchart A, Montarras D, Bodin C, Kume T, Vincent SD, Buckingham M, Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis. Development. 2016 Mar 01;143(5):872-9
1	J:338696 Maynard TM, Horvath A, Bernot JP, Karpinski BA, Tavares ALP, Shah A, Zheng Q, Spurr L, Olender J, Moody SA, Fraser CM, LaMantia AS, Lee NH, Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome. Hum Mol Genet. 2020 Apr 15;29(6):1002-1017
1*	J:87726 Milewski RC, Chi NC, Li J, Brown C, Lu MM, Epstein JA, Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development. 2004 Feb;131(4):829-37
1	J:157031 Misra K, Matise MP, A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol. 2010 Jan 1;337(1):74-83
1	J:202820 Moore S, Ribes V, Terriente J, Wilkinson D, Relaix F, Briscoe J, Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube. PLoS Genet. 2013 Oct;9(10):e1003811
1	J:242767 Nunes AM, Wuebbles RD, Sarathy A, Fontelonga TM, Deries M, Burkin DJ, Thorsteinsdottir S, Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy. Hum Mol Genet. 2017 Jun 01;26(11):2018-2033
1	J:239276 Ohayon D, Venteo S, Sonrier C, Lafon PA, Garces A, Valmier J, Rivat C, Topilko P, Carroll P, Pattyn A, Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons. Dev Cell. 2015 May 04;33(3):343-50
1	J:115577 Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK, Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
1	J:308914 Panoutsopoulos AA, De Crescenzo AH, Lee A, Lu AM, Ross AP, Borodinsky LN, Marcucio R, Trainor PA, Zarbalis KS, Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities. Front Cell Dev Biol. 2020;8:510063
1	J:326945 Ramirez de Acuna F, Hernandez-Torres F, Rodriguez-Outeirino L, Dominguez JN, Matias-Valiente L, Sanchez-Fernandez C, Franco D, Aranega AE, Pitx2 Differentially Regulates the Distinct Phases of Myogenic Program and Delineates Satellite Cell Lineages During Muscle Development. Front Cell Dev Biol. 2022;10:940622
1*	J:103820 Reiter JF, Skarnes WC, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
1*	J:90568 Relaix F, Rocancourt D, Mansouri A, Buckingham M, Divergent functions of murine Pax3 and Pax7 in limb muscle development. Genes Dev. 2004 May 1;18(9):1088-105
1	J:99365 Relaix F, Rocancourt D, Mansouri A, Buckingham M, A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature. 2005 Jun 16;435(7044):948-53
1	J:119082 Schuster-Gossler K, Cordes R, Gossler A, Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):537-42
1*	J:117808 Shih HP, Gross MK, Kioussi C, Expression pattern of the homeodomain transcription factor Pitx2 during muscle development. Gene Expr Patterns. 2007 Feb;7(4):441-51
1	J:239455 Shin J, Watanabe S, Hoelper S, Kruger M, Kostin S, Poling J, Kubin T, Braun T, BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife. 2016 Dec 01;5:e18351
1	J:142352 Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP, Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008 Nov 21;322(5905):1247-50
1	J:120053 Vasyutina E, Lenhard DC, Wende H, Erdmann B, Epstein JA, Birchmeier C, RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4443-8
1	J:186268 Vincent SD, Mayeuf A, Niro C, Saitou M, Buckingham M, Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo. Mol Biol Evol. 2012 Oct;29(10):3181-91
1	J:284292 Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X, Zheng Y, Sun M, Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 1;9(5):520
1	J:178868 Watanabe S, Matsushita S, Hayasaka M, Hanaoka K, Generation of a conditional null allele of Lbx1. Genesis. 2011 Oct;49(10):803-10
1	J:204000 Wood WM, Etemad S, Yamamoto M, Goldhamer DJ, MyoD-expressing progenitors are essential for skeletal myogenesis and satellite cell development. Dev Biol. 2013 Dec 1;384(1):114-27
1	J:336860 Wurmser M, Madani R, Chaverot N, Backer S, Borok M, Dos Santos M, Comai G, Tajbakhsh S, Relaix F, Santolini M, Sambasivan R, Jiang R, Maire P, Overlapping functions of SIX homeoproteins during embryonic myogenesis. PLoS Genet. 2023 Jun;19(6):e1010781
1	J:331054 Zhang W, Yu J, Fu G, Li J, Huang H, Liu J, Yu D, Qiu M, Li F, ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development. Development. 2022 Nov 1;149(21):dev200788
1*	J:325429 Zhou HM, Conway SJ, Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero. J Dev Biol. 2022 May 17;10(2)
1	J:132613 Zhou HM, Wang J, Rogers R, Conway SJ, Lineage-specific responses to reduced embryonic Pax3 expression levels. Dev Biol. 2008 Mar 15;315(2):369-82